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Sulfates are the foremost circulating conjugates of ethinyl estradiol and glucuronides predominate in urine. The main oxidative metabolite is two-hydroxy ethinyl estradiol, formed with the CYP3A4 isoform of cytochrome P450. Part of the main-pass metabolism of ethinyl estradiol is believed to take place in gastrointestinal mucosa. Ethinyl estradiol